Inhibition of endothelial nitric oxide synthase activity and suppression of endothelium-dependent vasorelaxation by 1,2-naphthoquinone
, a component of diesel exhaust particles.
Biodegradation products of Acid Orange 7 and Disperse Orange 3, by white rot fungus, Pleurotus ostreatus, were identified as 4-hydroxybenzenesulfonic acid, benzenesulfonic acid, 1,2-naphthoquinone
, 4-nitrophenol, nitrobenzene, 4-nitroanisole, and 4-nitroaniline.
Toxicological studies have found associations between inflammation and exposure to diesel exhaust constituents, such as the organic electrophile 1,2-naphthoquinone
BACKGROUND: Toxicological studies have correlated inflammatory effects of diesel exhaust particles (DEP) with its organic, constituents, such as the organic electrophile 1,2-naphthoquinone (1,2-NQ).
In the present study, we expanded this approach to include an investigation of the relationship between specific oxidant events in the cytosol and mitochondria and altered gene expression induced by the redox-active air contaminant, 1,2-naphthoquinone (1,2-NQ).
1,2-Naphthoquinone disrupts the function of cAMP response element-binding protein through covalent modification.
Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor.
1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.
Initial response and cellular protection through the Keap1/Nrf2 system during the exposure of primary mouse hepatocytes to 1,2-naphthoquinone.
Formation of depurinating N3adenine and N7guanine adducts after reaction of 1,2-naphthoquinone
or enzyme-activated 1,2-dihydroxynaphthalene with DNA.
For instance, among quinones, phenanthraquinone and 1,2-naphthoquinone
caused mitochondrial swelling, while anthraquinone did not.
(NQ), 1,4-NQ, phenanthraquinone (PQ), and anthraquinone (AQ) were analyzed by the electron-impact gas chromatography/mass spectrometry technique using an HP MSD mass spectrometer (Hewlitt Packard, Palo Alto, CA) equipped with an automatic sampler (Cho et al.