calcitriol

(redirected from 1,25-dihydroxycholecalciferol)
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calcitriol

[‚kal·sə′trī‚ōl]
(biochemistry)
1,25-dihydroxycholecalciferol, the form of vitamin D that is involved in intestinal absorption of Ca2+and Ca2+resorption by bone.
References in periodicals archive ?
The effects of dietary cholecalciferol steroids and gonadal hormone implantation on plasma 1,25-dihydroxycholecalciferol and bone calcification in preovulatory and senescent female Japanese quail.
After isomerisation of previtamin D in the skin, 25-hydroxylation in the liver and 1[alpha]-hydroxylation in the kidney, the active form 1,25-dihydroxycholecalciferol may exert the beneficial effects in the prevention and treatment of several diseases, namely in rickets, osteomalacia and osteoporosis.
The effects of 1,25-dihydroxycholecalciferol and phytase on the natural phytate phosphorus utilization by laying hens.
EVIDENCE FOR PERSISTENT VITAMIN D 1-ALPHA-HYDROXYLATION IN HEMODIALYSIS PATIENTS: EVOLUTION OF SERUM 1,25-DIHYDROXYCHOLECALCIFEROL AFTER 6 MONTHS OF 25-HYDROXYCHOLECALCIFEROL TREATMENT.
The outcomes studied included maternal/neonatal circulating serum vitamin D (25-OHD) levels at delivery, achieving 25-OHD of 80 nmol/L or more, and achieving 25-OHD concentration for maximal 1,25-dihydroxycholecalciferol (1,25-OH2D) production.
153), (154) The use of sunlight is known to enhance activation of 1,25-dihydroxycholecalciferol (active vitamin D3), an important immune modulator and calcium regulator; to enhance maturation of B lymphocytes; and to stimulate connective tissue synthesis.
It is also known, based on in vitro studies, that toll-like receptor stimulation of human macrophages induces expression of the vitamin D receptor as well as an enzyme, CYP27B1, which converts 25-hydroxycholecalciferol into immunologically active 1,25-dihydroxycholecalciferol, which then induces expression of cathelicidin in myeloid dendritic cells and keratinocytes.
In in vitro studies 1,25-dihydroxycholecalciferol had significant immunomodulatory effects leading to a shift in cytokine profile of T-helper (Th1 to Th2) and reduced antigen presentation (96).
Association between age, blood lead concentration, and serum 1,25-dihydroxycholecalciferol levels in children.
Increases in serum phosphate and decreases in 1,25-dihydroxycholecalciferol (vitamin D3) lead to a reduction in calcium absorption and disruption of the phosphorous-calcium balance.
Women lose bone calcium rapidly in the post--menopausal years, because of age--related changes in parathyroid hormone, 1,25-dihydroxycholecalciferol and estrogen levels which predispose them to osteoporosis (Pinn, 1991).