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Putrescine
(redirected from 1,4-diaminobutane)

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putrescine: see decay of organic matter decay of organic matter or putrefaction, process whereby heterotrophic organisms, including some bacteria, fungi, saprophytic plants, and lower animals, utilize the remains of once-living tissue as a source of nutrition.
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Putrescine 

(1,4-tetramethylenediamine), NH2(CH2)4NH2, one of the biogenic amines. Putrescine is a crystalline substance, with a melting point of 27°-28°C. It was first discovered in the products of the putrefactive decomposition of proteins. It is formed during the bacterial decarboxylation of the amino acid ornithine. In organic tissue, putrescine serves as the source compound for the synthesis of the physiologically active poly-amines spermidine and spermine. These substances, together with putrescine, cadaverine, and other diamines, are constituents of ribosomes and help support the ribosome structure.



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The best substrates for all preparations are 1,4-diaminobutane (putrescine) and 1,5-diaminopentane (cadaverine), which in nature are produced along with histamine and other biogenic amines in protein hydrolysis during putrefaction of tissues both in living and dead organisms.
In a first step, the enzyme is reacted in an organic solvent with a bifunctional monomer such as p-phenylene diisocyanate, 4-methyl-m-phenylene diisocyanate or 4,4'-methylenebisphenyl diisocyanate, and in a second step a bifunctional amine such as N-phenylethylenediamine, 1,6-diaminohexane, N,N'-diethyl-ethylenediamine or 1,4-diaminobutane is added.
T4T-dimethyl T4T-dimethyl was synthesized and purified according to route II for T2T-dimethyl as previously described [8], except that 1,2-diaminoethane was replaced by 1,4-diaminobutane.
 
 
 
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