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dioxin
(redirected from 2,3,7,8-tetrachlorodibenzo-p-dioxin)

   Also found in: Medical, Acronyms, Wikipedia, Hutchinson 0.02 sec.

dioxin

Aromatic compound, any of a group of contaminants produced in making herbicides (e.g., Agent Orange), disinfectants, and other agents. Their basic chemical structure consists of two benzene rings connected by a pair of oxygen atoms; when substituents on the rings are chlorine atoms, the molecules are particularly toxic. The best-known, usually called simply dioxin, is 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). It is extremely stable chemically; it does not dissolve in water but dissolves in oils (and thus accumulates in body fat). The extent of its human toxicity is disputed and the subject of continuing research.


dioxin [dī′äk·sən]
(organic chemistry)
A member of a family of highly toxic chlorinated aromatic hydrocarbons; found in a number of chemical products as lipophilic contaminants. Also known as polychlorinated dibenzo-para-dioxin.


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Source: Adapted from "Draft Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds," Volume 3, Chapter 3, Table 3-56, U.
The most toxic and notorious member of the family is 2,3,7,8-tetrachlorodibenzo-p-dioxin, or TCDD, widely known as the contaminant in the Vietnam War herbicide Agent Orange.
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with increased risk for cancer, diabetes, and reproductive toxicities in numerous epidemiologic studies (Schecter and Gasiewicz 2003).
 
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