A review of several published reports attribute the higher Gleason scores observed in the groups taking the 5-alpha reductase inhibitors
(Avodart[R] or Proscar[R]) to the fact that it was easier to find high-grade cancers in the shrunken glands of men taking these drugs compared to the much larger glands of men in the placebo group.
The PCPT found an overall 25% relative risk reduction for prostate cancer in men who took the 5-alpha reductase inhibitor
finasteride for 1-7 years.
To our knowledge, studies examining the efficacy and the adverse effects of the combination therapy of PDE-5 inhibitors with 5-alpha reductase inhibitors
have not yet been published.
The two main classes of BPH drugs: alpha blockers like Flomax and UroXatral, which relax the muscles of the bladder neck and prostate, and 5-alpha reductase inhibitors
like Proscar and Avodart, which lower levels of hormones produced by the prostate.
The findings suggest that men with early baldness may benefit from routine prostate cancer screening or preventive measures that could include the systematic use of 5-alpha reductase inhibitors
, the researchers wrote (doi:10.
Whilst some symptoms of BPH are successfully addressed by the standard BPH therapies of alpha blockers and 5-alpha reductase inhibitors
, nocturia remains inadequately treated.
Medical treatments for BPH include 5-alpha reductase inhibitors
(5-ARIs), which block the conversion of testosterone to dihydrotestosterone (DHT) via 5-alpha reductase (5-AR).
Men were asked to take one of the 5-alpha reductase inhibitors
or a placebo in a double-blind, randomized, controlled study over a number of years.