fluorouracil

(redirected from 5-fluorouracil)
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fluorouracil:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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fluorouracil

[¦flu̇r·ō′yu̇r·ə‚sil]
(pharmacology)
C4H3FN2O2 Crystals that decompose at 282-283°C; used as an antineoplastic drug and as an inhibitor of deoxyribonucleic acid synthesis. Also known as 2,4-dioxo-5-fluoropyrimidine; 5-FU.
References in periodicals archive ?
After this period, cells were incubated separately with increasing concentrations of 5-fluorouracil or phenylpropanoids (0.
The most common adverse reactions (>50%) in patients with advanced colorectal cancer receiving FUSILEV in combination with 5-fluorouracil were diarrhea, nausea and stomatitis.
Although bisabololoxide A at 10 [micro]M does not significantly potentiate the inhibitory action of 5-fluorouracil on the growth of K562 cells, the compound may reduce the dose of 5-fluorouracil, that decreases the incidence of side effect.
Triplet therapy with oxaliplatin, irinotecan, 5-fluorouracil and folinic acid within a combined modality approach in patients with liver metastases from colorectal cancer.
Antithrombotic treatment in protection against thrombogenic effects of 5-fluorouracil on vascular endothelium: a scanning microscopy evaluation.
Patients with advanced colorectal cancer who had previously been treated with irinotecan and 5-fluorouracil were randomized to one of three study arms: FOL-FOX4 alone, 10 mg/kg of bevacizumab given intravenously once every 2 weeks, or both regimens.
Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.
Scientists don't understand how the two drugs work together, but they speculate that levamisole stimulates the immune system and somehow interacts with 5-fluorouracil to destroy cancer cells.
About My5-FU Saladax's first commercially available test for innovative dose management; My5-FU measures levels of 5-fluorouracil (5-FU), a widely used chemotherapy drug used in conjunction with other drugs in first-line therapy for colorectal cancer and other solid tumors.
Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil
sibthorpioides is comparable to that of the common antitumor agent 5-fluorouracil.
William Steward, professor of oncology at the University of Leicester (England), led a phase I/II trial in which 35 patients were treated with escalating doses of the experimental compound, called PTK787/ZK, along with FOLFOX-4 chemotherapy (oxaliplatin, 5-fluorouracil, and leucovorin), a standard combination therapy for advanced colorectal cancer.