(6MP) is an oral chemotherapy drug often used to treat acute lymphocytic leukemia (ALL), the most common blood cancer in children.
During this hospitalization, the 6-mercaptopurine
and infliximab were discontinued, but the patient remained on low dose corticosteroids.
Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine
At 12 hours after admission, her blood methotrexate and 6-mercaptopurine
concentrations were 0.
Maintenance: Patients who achieved a complete response after consolidation treatment should continue on maintenance of one to two years of ATRA, which may be combined with 6-mercaptopurine
During maintenance therapy with 6-mercaptopurine
and Methotrexate she developed bicytopenia (macrocytic anemia and thrombocytopenia) one year after the diagnosis of the malignant lymphoma.
Traditionally these drugs (such as infliximab and adalimumab) have been used in cases refractory to standard treatment with corticosteroids and immunomodulators (such as azathiorine, 6-mercaptopurine
hepatitis, nephropathy, allergic reaction and 6-mercaptopurine
toxicity (Kong et al.
Many laboratories now offer this test as a preventive measure for patients receiving azathioprine or 6-mercaptopurine
Metabolism of 6-mercaptopurine
in the erythrocytes, liver, and kidney of rats during multiple-dose regimens.
The pathogenesis of drug-induced pancreatitis may be due to an idiosyncratic response in some circumstances (eg, 6-mercaptopurine
, aminosalicylates, sulfonamides) or to direct toxicity (eg, diuretics, sulfonamides).
Background: Genetic polymorphisms in thiopurine methyltransferase (TPMT) influence the metabolism of azathioprine (AZA) and 6-mercaptopurine
(6-MP) in patients with inflammatory bowel disease (IBD).