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see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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References in periodicals archive ?
6-Mercaptopurine (6MP) is an oral chemotherapy drug often used to treat acute lymphocytic leukemia (ALL), the most common blood cancer in children.
During this hospitalization, the 6-mercaptopurine and infliximab were discontinued, but the patient remained on low dose corticosteroids.
Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine.
At 12 hours after admission, her blood methotrexate and 6-mercaptopurine concentrations were 0.
Maintenance: Patients who achieved a complete response after consolidation treatment should continue on maintenance of one to two years of ATRA, which may be combined with 6-mercaptopurine and methotrexate.
During maintenance therapy with 6-mercaptopurine and Methotrexate she developed bicytopenia (macrocytic anemia and thrombocytopenia) one year after the diagnosis of the malignant lymphoma.
Traditionally these drugs (such as infliximab and adalimumab) have been used in cases refractory to standard treatment with corticosteroids and immunomodulators (such as azathiorine, 6-mercaptopurine or methotrexate).
Many laboratories now offer this test as a preventive measure for patients receiving azathioprine or 6-mercaptopurine.
Metabolism of 6-mercaptopurine in the erythrocytes, liver, and kidney of rats during multiple-dose regimens.
The pathogenesis of drug-induced pancreatitis may be due to an idiosyncratic response in some circumstances (eg, 6-mercaptopurine, aminosalicylates, sulfonamides) or to direct toxicity (eg, diuretics, sulfonamides).
Background: Genetic polymorphisms in thiopurine methyltransferase (TPMT) influence the metabolism of azathioprine (AZA) and 6-mercaptopurine (6-MP) in patients with inflammatory bowel disease (IBD).