ACE inhibitor

(redirected from ACE inhibitors)
Also found in: Dictionary, Thesaurus, Medical, Legal.
Related to ACE inhibitors: Beta blockers, Diuretics, Calcium channel blockers, ARBS

ACE inhibitor

(ā'sē'ē`, ās) or

angiotensin-converting enzyme inhibitor

(ăn'jēōtĕn`sĭn), drug used to reduce elevated blood pressure (see hypertensionhypertension
or high blood pressure,
elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
..... Click the link for more information.
), to treat congestive heart failurecongestive heart failure,
inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.
..... Click the link for more information.
, and to alleviate strain on hearts damaged as a result of a heart attack (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
..... Click the link for more information.
). ACE inhibitors block production of an enzyme that helps convert the protein angiotensin 1 into angiotensin 2, a protein that makes blood vessels constrict and promotes retention of fluid, raising blood pressure. Thus ACE inhibitors act to widen the blood vessels and make it easier for the heart to pump blood through the body. captopril (Capoten), ramipril (Altace), and enalapril (Vasotec) are commonly used ACE inhibitors. Angiotensin-receptor blockers (ARBs), such as losartan (Cozaar) and valsartan (Diovan), reduce hypertension by displacing angiotensin 2 from receptors on the surface of cells. ARBs are used as alternatives to the less expensive ACE inhibitors because they have fewer side effects.
References in periodicals archive ?
13) The diagnosis is made when a patient on an ACE inhibitor presents with nonpruritic, nontender, well-demarcated areas of angioedema and other causes have been ruled out.
Compared with those not taking ACE inhibitors, those on these drugs experienced marginally slower rates of cognitive decline.
04-g/cm2 greater in the 137 subjects on an ACE inhibitor for at least 5 years than in men not on long-term therapy with a drug in this class.
They found that physicians were less likely to prescribe ACE inhibitors in patients with moderate CKD (defined as a creatinine clearance of 21 to 40 mL/min) than in patients with CrCl > 60 mL/min (Hsu et al.
If there is an indication for an ACE inhibitor, we might as well use one that crosses the blood-brain barrier," Dr.
LONDON, July 9 /PRNewswire/ -- Apotex UK Ltd, the British arm of Canada's largest generics manufacturer, today announced that it had won a patent dispute, allowing the company to launch its generic version of the popular ACE Inhibitor, perindopril to the NHS.
However, the determination of a causal association between ACE inhibitors and pancreatitis requires a multidisciplinary approach including clinical, pharmacological and epidemiologic methods.
A review of the records of 29,507 infants in Tennessee showed that 209 babies had been exposed to ACE inhibitors during the first trimester in the womb.
However, the agency considers the study findings "preliminary" and will not change the black box warning, or the designation of ACE inhibitors as pregnancy category D drugs, "until we've examined the findings and sought additional evaluation from other information sources," said Dr.
Although it is often stated that ACE inhibitors don't work as well in African Americans, a meta-analysis prepared for the Agency for Health Care Research and Quality examined the three placebo-controlled trials of ACE inhibitors stratified by race and concluded there was no mortality difference in the use of ACE inhibitors between African-Americans and Caucasians.
The study shows the benefits of ACE inhibitors in heart patients for whom the benefits of the drugs have been controversial, Masoudi said.
It is estimated that about 30% of the 218,000 people in the UK who survive a heart attack do not receive traditional Ace inhibitor style drugs to help prevent a further attack.