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acetylcholine receptor
(redirected from ACh receptor)

   Also found in: Wikipedia 0.01 sec.
acetylcholine receptor [ə‚sed·əl ′kō‚lēn ri‚sep·tər]
(cell and molecular biology)
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance; muscarinic acetylcholine receptors are G-protein-linked receptors inducing membrane ion channel changes or intracellular processes such as smooth muscle contraction.


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AChE is responsible for the rapid cleavage of the neurotransmitter ACh in the synapse, thereby regenerating the ACh receptor and the excitability of the postsynaptical membrane.
Since the lesioning procedure did not ensure a precise and complete removal of the efferent system, a genetically altered mouse ([euro]9 Ach receptor subunit knockout) was developed in which the peripheral cochlear Ach receptor sites were deleted.
 
 
 
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