lymphoma

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Related to ALCL: ACL

lymphoma,

a cancer of the tissue of the lymphatic systemlymphatic system
, network of vessels carrying lymph, or tissue-cleansing fluid, from the tissues into the veins of the circulatory system. The lymphatic system functions along with the circulatory system in absorbing nutrients from the small intestines.
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. There are two categories of lymphomas. One type is termed Hodgkin's diseaseHodgkin's disease,
a type of cancer of the lymphatic system. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly.
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, the other, non-Hodgkin's lymphoma (see lymphoma, non-Hodgkin'slymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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). See also neoplasmneoplasm
or tumor,
tissue composed of cells that grow in an abnormal way. Normal tissue is growth-limited, i.e., cell reproduction is equal to cell death. Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair
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.

lymphoma

[lim′fō·mə]
(medicine)
Any neoplasm, usually malignant, of the lymphoid tissues.
References in periodicals archive ?
33-37) ALK- ALCL tumors arising in the skin and gastrointestinal tract must be distinguished from C-ALCL and enteropathy-associated T-cell lymphoma.
Macrophages are often markedly increased in the small cell variant of ALCL and may display erythrophagocytosis.
Two patients had a history of cutaneous ALCL 1 year and 4 years, respectively, before the diagnosis of ALCL in the breast.
In this study, we describe the immunophenotypic findings of 23 cases of ALCL, all with known ALK expression, assessed by multiparameter flow cytometry.
Despite the high frequency of extranodal disease in ALK-negative ALCL, to the best of our knowledge, there are few reports of ALCL affecting primarily the breast, (5, 8, 9) and only 1 previous report of the sarcomatoid variant in this site.
The characteristic features of primary cutaneous ALCL include solitary or multiple erythematous nodules or tumours that appear on any part of the body, often grow very slowly, and may be present for a long time before being diagnosed.
Methods: ALCL, leukaemia and breast cancer cells, and normal peripheral blood mononuclear cells (PBMCs) were treated with isolated sesquiterpene lactones and analysed for cell cycle progression, proliferation, mitochondrial activity, apoptosis, protein and mRNA expression, NF-[kappa]B and cytochrome P450 activity, 12(S)-HETE production and lymphendothelial intravasation.
Out of 25 cases, 22(88%) were ALCL ALK positive, 2(8%) were ALCL ALK negative and 1(4%) case was cutaneous ALCL.
The morphologic spectrum of ALCL is broad and includes common cases as well as morphologic variants such as small cell, lymphohistiocytic, and sarcomatoid.
1,2) Although there has been growing concern with regards to the association of ALCL and breast implants due to the natural characteristics (very low frequency and extremely delayed presentation) of the ALCL presentation in patients with breast implants, confirming a powerful causative relationship with a significant statistical value is going to be very challenging.
The site started the “Drive Breast Cancer Awareness” campaign in 2011 when it founder and Editor-in-Chief, Christina Selter, was diagnosed with a rare form of liquid breast cancer known as ALCL.