APAP


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

APAP

(organic chemistry)
References in periodicals archive ?
APAP was well-tolerated by human, hence became a common household analgesic (Hinson et al.
7 ml/kg) once daily by orogastric tube for 28 days followed by APAP (500 mg/kg)at single dose orally on 28th day.
At therapeutic doses, most APAP is metabolized by cytochrome P450 enzymes to form the highly reactive intermediate metabolite N-acetyl-p-benzoquinoneimine (NAPQI), which is readily detoxified via conjugation with glutathione (GSH) under normal conditions.
The hypothesis that APAP acts as a prooxidant in the airways and enhances the response to ETS was tested in a mouse model by determining whether APAP and/or APAP + ETS a) cause a loss of GSH, and b) activate the oxidant stress response pathway, as indicated by the activation of two NRF2-dependent genes: Gclc and Nqol.
the APAP concentration has been used according to our pilot study).
Owing to unique metabolism in kidneys even therapeutic doses of APAP have been reported to produce renal lesions4.
The liver of the APAP exclusively intoxicated rats showed moderate portal congestion with periportal hepatic necrosis, cellular infiltration, and foci of haemorrhage into the hepatic parenchyma.
At therapeutic doses, APAP is metabolized by cytochrome P450 to form the highly reactive species, N-acetyl-p-benzoquinoneimine (NAPQI), which under normal conditions is readily detoxified by conjugation with glutathione (GSH).
APAP machines don't provide continuous pressure, but instead detect and respond to changes in upper airway flow or resistance patterns; the idea is to use the minimal effective pressure needed to maintain airway patency, which can change for various reasons, even body position
In Architecture, juror Minsuk Cho, AIA highlighted Honor winner LOT-EK's APAP Openschool.
APAP devices may also assist in the initial diagnosis of OSAS and help determine an effective level of fixed pressure for treatment with conventional CPAP, by detecting and recording respiratory disturbances without correcting them.
APAP, which helps fund the fest (UTR's annual budget varies between $500,000 and $650,000), boasts members from all 50 states and 15 countries, so UTR has become one of the few theater festivals in the country tied to a group repping hundreds of presenting venues.