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ARQ 197 is the lead product from ArQule's new kinase inhibitor discovery program.
We are excited to enter into a partnership with a world-class Japanese company whose oncology franchise positions it strongly in Asian markets and whose resources will allow it to develop and commercialize ARQ 197 on a timely basis," said Dr.
Brainstem from healthy homozygous ARQ sheep was inoculated in PoPrP-Tg001 mice as a negative control.
Secondary endpoints include OS in the subpopulation of patients with epidermal growth factor receptor (EGFR) wild type, progression-free survival (PFS) in the ITT population, and further assessment of the safety of ARQ 197 in combination with erlotinib.
Sheep with genotype ARQ/ ARQ in scrapie flocks are commonly affected by the disease (8).
I am pleased that we have initiated formal GLP toxicology studies and are on schedule to advance another small molecule candidate compound, ARQ 197, along the continuum from discovery to clinical development," said Dr.
Patients were randomized one-to-one to receive either the combination of ARQ 197 plus erlotinib or placebo plus erlotinib.
The poster presentation reports interim results that demonstrate clinical tolerability, favorable pharmacokinetics, and evidence of anti-tumor activity of ARQ 501 in patients with advanced solid tumors who had failed chemotherapy.
ArQule and DAIICHI SANKYO will co-develop ARQ 197, a proprietary, orally administered, small molecule inhibitor of the c-Met receptor tyrosine kinase, to treat cancer.
ArQule anticipates that this component will be followed by a phase 2 study exploring the use of ARQ 501 and gemcitabine in patients with advanced cancer.
We look forward to characterizing the activity of ARQ 087 in the clinical setting.
today announced that it had successfully enrolled its first patient in a Phase 1b combination trial of ARQ 501 and Taxotere.
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