Other areas include the targeting or avoidance of epitopes associated with the Th1 and Th2 response; different mechanistic approaches to the targeting of Abeta
Molecular chaperones are known for their propensity to respond to disease-producing misfolded proteins, which is how the body views excessive Abeta
Louis, who collaborated with him in studying the brains of freely moving transgenic mice that overexpress human Abeta
targeting drugs and pipeline candidate drugs/treatments from marketed products through to preclinical studies.
Supporting that notion, the researchers found that levels of 38A were more than 10 times higher in brain cells from AD patients than in controls and that 38A hiked output of the more dangerous Abeta
Some of the most important advances in AD biomarker discovery have been provided by imaging methods such as MRI and PET, which have helped to map the time-course of this disease, as well as changes relating to molecules such as Abeta
Taken together, these results suggest that the combination with ET and LA may contribute to protect the neuron injury induced by Abeta
peptides and may be considered an effective therapeutic strategy for human subjects suffering from AD.
plays a key role in the development of Alzheimer's disease.
The presentation is entitled: "How to change and monitor the rates of ABeta
amyloid accumulation and cognitive decline in Alzheimer's disease".
is one of many proteins found to be associated with the disease.
CogRx), an innovative research and drug discovery organization focused on the development of novel disease-modifying therapeutics for neurodegenerative diseases, announced today that its small molecule soluble Abeta
receptor antagonist program for the treatment of Alzheimer's disease (AD) has been selected for funding by the National Institute on Aging (NIA)/NIH Alzheimer's Disease Drug Development Program (U01).
The triterpenes and polysaccharides from the mushrooms reduce the oxidative impact of destructive proteins such as Abeta
, the chief trigger of Alzheimer's disease, (16) and they protect brain cells from the inflammation known to cause Parkinson's disease.