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acetylcholine receptor

   Also found in: Medical, Acronyms, Wikipedia 0.01 sec.
acetylcholine receptor [ə‚sed·əl ′kō‚lēn ri‚sep·tər]
(cell and molecular biology)
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance; muscarinic acetylcholine receptors are G-protein-linked receptors inducing membrane ion channel changes or intracellular processes such as smooth muscle contraction.


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5) As 2-weeks pass, brain acetylcholine receptor counts up-regulated in response to nicotine''s presence have now down-regulated and receptor binding has returned to levels seen in the brains of non-smokers.
Three of these four genes belong to nicotinic acetylcholine receptor gene families [19] which are the known targets of insecticides, neonicotinoids [20], as well as naturally derived spinisyns [21].
Previous studies have shown that an antagonist of nicotine acetylcholine receptors (nAChRs), called d-tubocurarine/a-Cobratoxin (a-CbT), may serve as an anticancer agent because it specifically targeted the a7 subunit of nAChRs, the area primarily associated with increased cell proliferation.
 
 
 
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