acyl-coenzyme A

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acyl-coenzyme A

[′a·səl kō′en‚zim ′ā]
(biochemistry)
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Higher expression of acyl-CoA dehydrogenase genes in adipose tissues of obese compared to lean pig breeds.
2006), catalyzes the synthesis of acyl-CoA from FAs; cardiac overexpression of ACSL can result in severe cardiomyopathy due to increased FA uptake and an ensuing accumulation of lipids (Chiu et al.
Primers for real time-PCR analysis Gene category Gene name GenBank ID Primer Growth hormone Growth hormone receptor NM_176608 Forward signaling (GHR) Reverse Signal transducer and NM_174617 Forward activator of Reverse transcription 5B (STAT5B) Insulin-like growth NM_001077828 Forward factor (IGF-1) Reverse Androgen receptor NM_001244127 Forward Reverse Myostatin NM_001001525 Forward Reverse Lipogenesis Fatty acid synthase NM_001012669 Forward (FASN) Reverse Fatty acid binding BT10868 Forward protein 4 (FABP4) Reverse Lipid Adipose triglyceride NM_001046005 Forward metabolism lipase (ATGL) Reverse Acyl-CoA synthetase NM_001076085.
4] Human genes: CYBB, cytochrome b-245, beta peptide; BRCA1, breast cancer 1, early onset; CFTR, cystic fibrosis transmembrane conductance regulator (ATP binding cassette sub-family C, member 7); BRCA2, breast cancer 2, early onset; ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain; CYP2C9, cyto chrome P450, family 2, subfamily C, polypeptide 9; VKORC1, vitamin K epoxide reductase complex, subunit 1; F2, coagulation factor II (thrombin); F5, coagulation factor V (proaccelerin, labile factor); MTHFR, methylenetetrahydrofolate reductase (NAD(P)H).
People who fast for one or two days experience an increase in fatty acyl-CoA levels.
and his laboratory at Brigham and Women's Hospital, demonstrated that Them1, a long chain fatty acyl-CoA thioesterase that is highly enriched in brown fat, plays an important role in regulating energy homeostasis.
The 40 gg of homogenized proteins were separated by SDS-PAGE using 8% for microsomal TG transfer protein (MTTP; 160 kDa) and 10% polyacrylamide separating gel for acyl-CoA dehydrogenase, C-4 to C-12 straight chain (ACADM; 45 kDa), with 5% stacking gels.
Therefore, NBS for IVA may also detect patients with 2-methylbutyrylCoA dehydrogenase (short/branched-chain acyl-CoA dehydrogenase) deficiency (SBCADD, OMIM #610006) caused by mutations in acyl-CoA dehydrogenase, short/branched chain (ACADSB) (600301) (2).
Furthermore, the treatment suppressed cardiac overexpression of mRNAs encoding for FA transport protein, peroxisome proliferator-activated receptor (PPAR)-alpha, carnitine palmitoyltransferase-1, acyl-CoA oxidase and 5'-AMP-activated protein kinase alpha2, and restored downregulated cardiac acetyl-CoA carboxylase mRNA expression in ZDF rats, whereas it showed little effect in Zucker lean rats.
Interestingly, the enzymes for lipid metabolism such as lipoprotein lipase (Lpl, 33-fold), cytosolic acyl-CoA thioesterase (Ctel, 5-fold), and proteasome 26S subunit ATPase-3 (Pmsc3, 4-fold) were increased.
27 /PRNewswire/ -- The March of Dimes and DHR's Division of Public Health announced today that Georgia's newborns are now being tested for Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD), one of the fatty acid oxidation disorders that causes severe illness, disabilities, or even death.
A good example of this is Very Long Chain Acyl-CoA Dehydrogenase deficiency (VLCAD).
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