pernicious anemia

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pernicious anemia:

see anemiaanemia
, condition in which the concentration of hemoglobin in the circulating blood is below normal. Such a condition is caused by a deficient number of erythrocytes (red blood cells), an abnormally low level of hemoglobin in the individual cells, or both these conditions
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pernicious anemia

[pər′nish·əs ə′nēm·ē·ə]
(medicine)
A megaloblastic macrocytic anemia resulting from lack of vitamin B12, secondary to gastric atrophy and loss of intrinsic factor necessary for vitamin B12 absorption, and accompanied by degeneration of the posterior and lateral columns of the spinal cord.