cause 40 to 50% of cases of Cushing's syndrome in pregnancy but only 15% cases of Cushing's syndrome in non-pregnant patients.
Aminotransferase levels and GGT were significantly elevated in Cushing's syndrome group when compared to adrenal adenoma
But the slope for diabetes was steeper among the adrenal adenoma
patients, and the prevalence exceeded 15% in patients over 60 years of age.
Caracteristics of the 14 patients with Cushing's syndrome Subject Typical Low-dose High-dose Cushingoid (1mg) (8/16mg) Features (*) dex-sup test dex-sup test 1 yes NS NS 2 yes NS S 3 yes NS -- 4 yes NS -- 5 yes NS S 6 yes NS NS 7 yes NS NS 8 yes NS S 9 yes NS S 10 yes NS -- 11 yes NS -- 12 yes NS -- 13 yes NS S 14 yes NS S Subject Abdominal MRI/CT Surgery Cure 1 Adrenal adenoma
Absolute threshold values [greater than or equal to] 60% and relative washout threshold [greater than or equal to] 40% have been found to be 98% sensitive and 92% specific for diagnosing adrenal adenomas
2 FAI 8 Secondary adrenal insufficiency ADE 33 182 MER 36 124 Adrenal adenoma
TUR 1377 1258 ORT 1145 1068 Mean [+ or -] SD 973 [+ or -] 266 (n=10) Range 568-1377 Cushing disease MON 411 4389 LAN 372 3925 Ectopic ACTH secretion BRE 9865 MOR 1574 IMO 786 Mean [+ or -] SD 2959 [+ or -] 3874 (n=5) Range 786-9865 Cushing disease under OP'DDD MON 282 Ectopic ACTH under OP'DDD BRE 569 MOR 358 Chronic renal insufficiency Mean-SD 387 [+ or -] 98 (n=10) Range 265 -568 11-HSD deficiency GON J-C 215 GON A 193 GON A (c) 146 Serum E, nmol/L [t.
Often, the specific diagnosis of adrenal adenoma
can also be made based on CT attenuation measurements, CT washout criteria, or signal loss on opposed-phase MR imaging.
The rationale for determining the lipid content of an adrenal lesion is based on the finding that adrenal adenomas
contain variable amounts of intracellular lipid, whereas metastatic lesions generally do not.
Unilateral or bilateral resection may be performed for functioning adrenal adenomas
DDT also increased incidences of lung tumors and lymphomas in mice, incidences of liver tumors in rats, and incidences of adrenal adenomas
in hamsters (8).
In about one-half of these cases, the tumors are noncancerous growths of adrenal tissue, called adrenal adenomas
, which release excess cortisol into the blood.
11,12) Adrenal adenomas
will show low mean-attenuation values (< 10 HU on unenhanced images), compared with other masses, such as metastases or pheochromocytomas (Figure 8).