androgen

(redirected from Adrenal androgen)
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androgen

(ăn`drəjən): see testosteronetestosterone
, principal androgen, or male sex hormone. One of the group of compounds known as anabolic steroids, testosterone is secreted by the testes (see testis) but is also synthesized in small quantities in the ovaries, cortices of the adrenal glands, and placenta, usually
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.

Androgen

One of a class of steroid hormones. Androgens play a major role in the development and maintenance of masculine secondary sexual characters, for example, the seminal vesicle and prostate gland of the male mammal, and the comb, wattles, and spur of the male fowl. They also influence certain other secondary sexual characters, such as hair growth pattern and voice quality in humans. In the fowl, they affect the pattern and seasonal coloration of its feathers, as well as crowing. In addition, androgens affect nitrogen metabolism (anabolic). Androgens are produced in the testis, ovary, adrenal, and most likely, in the placenta. A small portion of the androgen is from corticoids, or adrenal cortex steroids, and from other C21 steroids, such as progesterone. See Hormone, Ovary, Progesterone, Steroid, Testis

androgen

[′an·drə·jən]
(biochemistry)
A class of steroid hormones produced in the testis and adrenal cortex which act to regulate masculine secondary sexual characteristics.
References in periodicals archive ?
The inherent enzyme block leads to increased adrenal precursor concentrations despite normalization of ACTH; thus glucocorticoidsmust be replaced at a supraphysiologic concentration to fully normalize adrenal androgens (1).
Neither male nor female athletes involved in endurance training demonstrate a change in serum concentration of any adrenal androgen (7).
The adrenal glands produce testosterone, pregnenolone, aldosterone, DHEA, progesterone, estrogen, and adrenal androgens.
conducted a study showing that intratumoral steroid biosynthesis contributes less androgen to the tumors than circulating adrenal androgens, suggesting the blockade of CYP17 as an interesting therapeutic target in AIPC patients (42).
The best way to prevent the problem is to avoid oversuppression of adrenal androgens via careful monitoring, said Dr.
The primary source of oestrogen in postmenopausal women is from fat, liver, muscle, and breast tissue; through a process that turns adrenal androgens (hormones secreted by the adrenal gland) into oestrogen.
The mechanism by which the vitamin works is unknown, the textbook notes, but may be related to alteration of blood levels of various hormones, including adrenal androgens and gonadotropins.
12,13,16,17] Potential mechanisms accounting for this include intratumoral amplification of the androgen receptor (AR), mutations of the AR, changes in levels of AR co-factors, increased expression of enzymes involved in androgen synthesis, enhanced intracellular conversion of adrenal androgens to testosterone and DHT within the tumour micro-environment, and ligand-independent activation of the AR.
Charles Hughes, MD] * Testosterone and Adrenal Androgens in Men; Estrogen and Progesterone Replacement in Women.
Although this pioneering study can be criticized for its lack of an experimental control group, its extremely limited sample size, and its use of a physically traumatized participant population, the results strongly suggested that adrenal androgens do influence what Waxenberg et al.
The lowering of adrenal androgens, which are known to drive tumor growth, has now become a key treatment goal for patients with CRPC.