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Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity.
Subsequently, acetaldehyde enters the mitochondria where it is converted to acetate by activated aldehyde dehydrogenases (ALDHs) (Sung et al.
Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients.
aldehyde dehydrogenase [ALDH]) in the blood-brain barrier, which may help keep brain acetaldehyde levels low (Petersen 1985; Tampier et al.
Acetaldehyde is then subsequently metabolized to acetate through the action of aldehyde dehydrogenase.
These investigations point to central roles for the enzyme aldehyde dehydrogenase (ALDH) and for certain molecules found in the animals' mitochondria, all of which are involved in alcohol metabolism.
At the time of enrollment, study subjects also submitted to alcohol dehydrogenase ("ADH") and aldehyde dehydrogenase ("ALDH2") genotyping.
The Company is currently running clinical trials in patients with aldehyde dehydrogenase ("ALDH2") deficiency, nephropathic cystinosis and non-alcoholic steatohepatitis ("NASH").
Raptor is involved in clinical development of its proprietary Delayed-Release Cysteamine ("DR Cysteamine") product candidate in nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease and Batten Disease, and its ConviviaTM product candidate in aldehyde dehydrogenase ("ALDH2") deficiency.
The Company's clinical division advances internally developed and in-licensed clinical-stage product candidates towards marketing approval and commercialization and is currently involved in clinical trials in patients with aldehyde dehydrogenase ("ALDH2") deficiency as part of Raptor's Convivia(TM) program and nephropathic cystinosis as part of Raptor's DR Cysteamine program.
cells and later with aldehyde dehydrogenase 1-positive ([ALDH1.
This reaction is mediated by the mitochondrial enzyme aldehyde dehydrogenase (ALDH).
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