Aleutian disease


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Aleutian disease

[ə′lü·shən diz‚ēz]
(veterinary medicine)
A disease of mink characterized by accumulations of plasma cells in several organs, hyaline changes in the walls of small arteries, and interstitial fibrosis of the kidneys.
References in periodicals archive ?
Nasdaq:HEPH) today announced the presentation of results indicating that its investigational immune regulating hormone, HE2200, significantly increased survival in a mink model of experimental Aleutian disease virus (ADV), a preclinical model of fatal lupus nephritis.
Recently, 2 mink farmers with vascular disease and microangiopathy, similar to conditions in mink with Aleutian disease, were found to have AMDV-specific antibodies and were AMDV DNA positive, suggesting a potential relationship between AMDV and human symptoms (12).
The splenic and nodal plasmacytosis and plasmacytic glomerulonephritis also prompted testing for Aleutian disease virus (ADV).