Laboratory parameters were remarkable for a mild elevation in her hepatic transaminases (alanine aminotransferase (ALT) of 106, and aspartate aminotransferase (AST) of 111) as well as an alkaline phosphotase
A significant decline in mRNA expression (humeral diaphysis) of osteocalcin combined with a decline in serum alkaline phosphotase
levels indicate a reduction in bone formation.
In the patients receiving atrasentan, a dose-dependent response was observed; in patients receiving the 10 mg dose of atrasentan, the total and bone alkaline phosphotase
concentrations remained consistent with baseline levels.