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alkaloid
(redirected from Alkaloids)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.04 sec.
alkaloid, any of a class of organic compounds composed of carbon, hydrogen, nitrogen, and usually oxygen that are often derived from plants. Although the name means alkalilike, some alkaloids do not exhibit alkaline properties. Many alkaloids, though poisons, have physiological effects that render them valuable as medicines. For example, curarine, found in the deadly extract curare curare (ky
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, is a powerful muscle relaxant; atropine atropine (ăt`rəpēn, –pĭn)
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 is used to dilate the pupils of the eyes; and physostigmine is a specific for certain muscular diseases. Narcotic alkaloids used in medicine include morphine morphine, principal derivative of opium , which is the juice in the unripe seed pods of the opium poppy , Papaver somniferum. It was first isolated from opium in 1803 by the German pharmacist F. W. A.
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 and codeine codeine (kō`dēn), alkaloid found in opium . It is a narcotic whose effects, though less potent, resemble those of morphine .
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 for the relief of pain and cocaine cocaine (kōkān`, kō`kān), alkaloid drug derived from the leaves of the coca shrub.
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 as a local anesthetic. Other common alkaloids include quinine quinine (kwī`nīn', kwĭnēn`), white crystalline alkaloid with a bitter taste.
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, caffeine caffeine (kăfēn`), odorless, slightly bitter alkaloid found in coffee , tea , kola nuts (see cola ), ilex plants (the source of the
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, nicotine nicotine, C10H14N2, poisonous, pale yellow, oily liquid alkaloid with a pungent odor and an acrid taste. It turns brown on exposure to air.
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, strychnine strychnine (strĭk`nĭn), bitter alkaloid drug derived from the seeds of a tree, Strychnos nux-vomica,
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, serotonin serotonin (sĕr'ətō`nĭn), organic compound that was first recognized as a powerful vasoconstrictor occurring in blood serum.
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, and LSD LSD or lysergic acid diethylamide
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. Aconitine is the alkaloid of aconite aconite (ăk`ənīt), monkshood, or wolfsbane, any of several species of the genus
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. Cinchonine and quinine are derived from cinchona cinchona (sĭngkō`nə) or chinchona
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, coniine is found in poison hemlock hemlock, any tree of the genus Tsuga, coniferous evergreens of the family Pinaceae ( pine family) native to North America and Asia. The common hemlock of E North America is T.
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, and reserpine is an extract of rauwolfia roots. Emetine is an alkaloid of ipecac ipecac (ĭp`ĭkăk), drug obtained from the dried roots of a creeping shrub, Cephaelis (or Psychotria)
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alkaloid

Basic (see base) organic compounds of plant origin, containing combined nitrogen. Alkaloids are amines, so their names usually end in “ine” (e.g., caffeine, nicotine, morphine, quinine). Most have complex chemical structures of multiple ring systems. They have diverse, important physiological effects on humans and other animals, but their functions in the plants that produce them are poorly understood. Some plants (e.g., opium poppy, ergot fungus) produce many different alkaloids, but most produce only one or a few. Certain plant families, including the poppy family (Papaveraceae) and the nightshade family (Solanaceae), are particularly rich in them. Alkaloids are extracted by dissolving the plant in dilute acid.


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The moths pick up alkaloids from several wild legumes in the Crotalaria genus.
Poppy seeds contain test-detectable levels of alkaloids such as morphine and codeine.
, copper, pyrrolizidine alkaloids, carbon tetrachloride, and phytotoxins) usually produce a periacinar zone 2-3 injury due to the low oxygen gradient (hypoxia) and high concentrations of, for example, cytochrome P450 isozymes (activation of reactive metabolites) of this zone (Kelly 1993; MacLachlan and Cullen 1995; Parkinson 1996).
 
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