are highly reactive chemicals that introduce alkyl groups into biologically active molecules and prevent normal functioning.
Ovarian damage may occur after high doses of abdominopelvic radiation and/ or alkylating agent
(cyclophosphamide, ifosfamide, mustard/procarbazine) chemotherapy are given.
work by inducing changes in DNA molecules that lead to the death of the cancer cell.
The survivors reported their children's health problems through questionnaires, and investigators also examined medical records from survivors and their children, focusing on survivors' history of radiation to the testes or ovaries and chemotherapy with alkylating agents
CHRONOS-3: A Phase III randomized, double-blind study evaluating the efficacy and safety of copanlisib in combination with rituximab versus rituximab monotherapy in patients with relapsed indolent NHL who have received at least one prior line of treatment, including rituximab and an alkylating agent
For caregivers and their patients, the therapeutic area that is at the forefront of attempts to mitigate exposure to cytotoxic drugs is clinical oncology, a field that continues to rely heavily on antineoplastics, a class that includes alkylating agents
and antimetabolites, to treat a wide range of cancers.
He is currently developing a high-throughput worm genome-wide microarray to screen compounds and develop signature profiles of response to a variety of toxicants, including bacterial toxins, chemicals, metals, and alkylating agents
Patients who received polyfunctional alkylating agents
such as cyclophosphamide and cisplatin developed no restenosis, as did those who received anthracycline antibiotics such as doxorubicin and bleomycin and those who got plant alkaloids such as vincristine, vinblastine, and paclitaxel.
PredictMDx for Brain, MDxHealth's most advanced personalized treatment product is a test for assessing patient response to alkylating agents
, a class of chemotherapy drugs.
CHRONOS-2: A Phase III randomized, double-blind, placebo-controlled study of copanlisib in rituximab refractory indolent NHL patients who have previously been treated with rituximab and alkylating agents
2] Leoni LM et al, Bendamustine (Treanda) Displays a Distinct Pattern of Cytotoxicity and Unique Mechanistic Features Compared with Other Alkylating Agents
Because cell biology studies indicate that many metal compounds enhance the genotoxic effects of known mutagens such as ultraviolet C radiation, X rays, benzo[a]pyrene, cisplatin, and DNA alkylating agents
, it has been postulated that environmental metals are comutagenic and potentiate the carcinogenic effects of DNA-damaging agents by inhibiting DNA repair processes (Hartwig et al.