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Thalassemia
(redirected from Alpha Thalassemia)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
thalassemia [‚thal·ə′sē·mē·ə]
(medicine)
A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.

Thalassemia 

(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.



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The patented test detects Alpha Thalassemia mutations and their use as predictors of blood-related disorders.
The evaluation of patients for alpha thalassemia carrier status is complicated by the fact that there are two different functional alpha globin genes--alpha 1 and alpha 2.
Kan applied this discovery to the development of a DNA test that was used successfully in 1976 to diagnose alpha thalassemia in an unborn fetus.
 
 
 
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