macroglobulin

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macroglobulin

[¦mak·rə′gläb·yə·lən]
(biochemistry)
Any gamma globulin with a sedimentation constant of 195.
References in periodicals archive ?
Alpha-2 macroglobulin attaches to the same cell surface protein as APP and APOE, the products of two other genes involved in Alzheimer's disease.
In addition, preliminary testing suggests that alfimeprase's lytic activity is localized to the site of delivery because within seconds of moving away from the clot and into the general circulation, it is inhibited by alpha-2 macroglobulin, a naturally occurring protein in our blood.
Endpoints included: the evaluation of safety; the evaluation of efficacy as calculated by the percentage of patients with partial or complete restoration of flow at two and four hours after treatment; measurement of the amount of time it took to re-perfuse the limb; determination of the open, surgery-free survival rates at 30 days after treatment with alfimeprase; comparison of the severity of interventions and the severity of ischemia after treatment with alfimeprase; determination of levels of alpha-2 macroglobulin consumption and the assessment of whether antibodies form in response to alfimeprase.
In addition, plasminogen and fibrinogen levels remained unchanged, supporting the belief that alfimeprase acts directly, independent of the plasminogen-plasmin system and that the systemic inactivation of alfimeprase by alpha-2 macroglobulin appeared to be effective.

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