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alpha helix
(redirected from Alpha-helix)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
alpha helix [′al·fə ′hē·liks]
(cell and molecular biology)
A spatial configuration of the polypeptide chains of proteins in which the chain assumes a helical form, 0.54 nanometer in pitch, 3.6 amino acids per turn, presenting the appearance of a hollow cylinder with radiating side groups.


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Proline +side chain of proline & alpha-amino group form a ring structure +it contains an imino group +unique geometry of proline (help forming of fibrous structure of collagen) +that interrupts alpha-helix found in globular proteins.
Whereas a single alpha-helix consists of an elegant spiral of 15 to 20 amino acids, the beta sheet requires 60 to 70 amino acids.
ALPHA-HELIX MIMETICS IN DRUG DISCOVERY 281 Hang Yin, Gui-In Lee, and Andrew D.
 
 
 
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