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melanocyte-stimulating hormone
(redirected from Alpha-msh)

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melanocyte-stimulating hormone [mə′lan·ə‚sīt ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein substance secreted by the intermediate lobe of the pituitary of humans which causes dispersion of pigment granules in the skin; similar to intermedins in other vertebrates. Abbreviated MSH. Also known as melanophore-dilating principle; melanophore hormone.


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Researchers found that blocking the PRCP enzyme keeps the alpha-MSH peptides from being degraded, resulting in higher levels of alpha-MSH and decreased appetite.
It is now established that leptin action in the hypothalamus in regulation of food intake and body weight is mediated by a neural circuitry comprising of orexigenic and anorectic signals, including NPY, MCH, galanin, orexin, GALP, alpha-MSH, NT, and CRH.
It works with the hormone alpha-MSH to darken the skin and reduce appetite.
 
 
 
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