In the obese rats alpha-MSH was low, despite an abundance of leptin and despite normal levels of gene expression both for its biochemical precursor protein called pro-opiomelanocortin (POMC) and for a key enzyme called PC2 that processes POMC in brain cells.
Nillni and his co-authors, including lead authors Isin Cakir and Nicole Cyr, conducted the new study to find out where the alpha-MSH deficit was coming from.
Alpha-MSH peptides were also barely more than half as abundant in obese rats as they were in healthy rats.
Nano-films containing alpha-MSH
also increased the number of these cells.
They also had higher levels of alpha-MSH
in the hypothalamus compared to control animals.
The study was designed to determine if there are changes in blood concentrations of alpha-MSH in patients with TBI or SAH.
Results show that baseline concentration of plasma alpha-MSH in patients with acute brain injury of either traumatic or vascular origin was significantly lower than in controls.
Scientists aimed to find alpha-MSH analogues with greater antimicrobial activity and to reach a better understanding of the peptide structure-antifungal activity relations against C.
In this structure-activity study, the team developed several compounds that have greater candidacidal activity than alpha-MSH and, in fact, one particular peptide (number 19) killed nearly 100 percent (99.