Thalassemia

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Related to Alpha-thalassemia: Beta-thalassemia, hemoglobin H disease

thalassemia

[‚thal·ə′sē·mē·ə]
(medicine)
A hereditary form of hemolytic anemia resulting from a defective synthesis of hemoglobin: thalassemia major is the homozygous state accompanied by clinical illness, and thalassemia minor is the heterozygous state and may not have evident clinical manifestations. Also known as Mediterranean anemia.

Thalassemia

 

(also thalassanemia), a familial hemolytic anemia, first detected in 1925 among inhabitants of the Mediterranean region. Thalassemia is caused by disturbances in hemoglobin synthesis.

References in periodicals archive ?
Genotypes of alpha-thalassemia and HbH disease in cukurova.
Molecular characterization of alpha-thalassemia in Adana, Turkey: a single center study.
4]) (20), which later became established markers of alpha-thalassemia.
Whereas alpha-thalassemia is usually caused by one or more deletions of the alpha-globin chain loci, not all alpha-thalassemias are due to gene deletions (24).
As conclusion, the incidence of alpha-thalassemia was much higher in the Iraqi Turks in the present study than that reported in studies from Turkey.
Esmael A, Ozturk A, Akar N: The incidence of alpha-thalassemia in Iraqi Turks Turk J Haematol 2011; 28: 235-236
Nonetheless, there are no data on the frequency of alpha-thalassemia gene deletions in Iraqi Turks.
Genotyping of alpha-thalassemia deletions using multiplex polymerase chain reactions and gold nanoparticle-filled capillary electrophoresis.
Binding of nitric oxide to thiols and hemes in hemoglobin H: implications for alpha-thalassemia and hypertension.