Development and application of an enzyme-linked immunosorbent assay for the quantitation of alternative complement pathway
activation in human serum.
Fromkes JJ, Thomas FB, Kraut EH: Activation of the alternative complement pathway
in ascitic fluid during spontaneous bacterial peritonitis.
Modulation of cell growth was evaluated by tritiated thymidine incorporation while inhibition of complement activity was measured on both classical and alternative complement pathways
(CP and AP respectively).
Agents which block properdin function may play a unique role in modulating the alternative complement pathway
in a manner that avoids broad based immune suppression.
Data support targeting the alternative complement pathway
using TT30 as an immunomodulatory compound for treating complement-mediated diseases
New synthetic inhibitor to the alternative complement pathway