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Rapid induction of death after LTE injection are similar to the lethal effects of wild mushroom Amanita phalloides amatoxins and lyophilized extract of Panaeolus subalteatus and Macrolepiotaprocera injected intraperitoneally at dose rate 1,000 mg/kg [2,12].
Amatoxins are thermostable (cooking, drying, and freezing do not alter their toxicity) and dialyzable.
Administration of cimetidine, a cytochrome P-450 inhibitor which inhibits the uptake of amatoxins by the mixed function oxidase system, and N-acetylcysteine (NAC), a glutathione precursor that binds amatoxin-related free radicals, have also been used in the treatment of amanitin intoxication.
Amatoxins, which constitute the second group of Amanita toxins, are cyclic octapeptides that interfere with DNA transcription (3).
Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis.