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Ames test

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Ames test [′āmz ‚test]
(analytical chemistry)
A bioassay that uses a set of histidine auxotrophic mutants ofSalmonella typhimuriumfor detecting mutagenic and possibly carcinogenic compounds.
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However, the Ames test is not a suitable model for the mutagenesis of metazoan cells, and thus may yield false-positive and false-negative results (Ashby and Styles 1978).
A novel approach using DNA-repair-deficient chicken DT40 cell lines ... by Ji, Kyunghee; Kogame, Toshiaki; Choi, Kyungho; Wang, Xin; Lee, Jinyoung; Taniguchi, Yoshihito; Taked / Environmental Health Perspectives
The Ames test misses around 40% of carcinogens, mainly because it lacks eukaryotic targets.
Preventing late stage failure due to genotoxic liabilities: speaking ... by Tweats, David; Walmsley, Richard / Pharma
Ames, creator of the standard Ames Test for carcinogens and director of the National Institute of Environmental Health Sciences Center at the University of California at Berkeley, has been highly critical of the EPA's continued use of long-discredited high-dose tests in rats that are useless in predicting infinitely smaller doses in humans.
Nurturing nature: federal agencies' track records show that the best ... by Jasper, William F. / The New American
 
 
 
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