Ames test


Also found in: Dictionary, Thesaurus, Medical, Legal, Financial, Wikipedia.

Ames test

[′āmz ‚test]
(analytical chemistry)
A bioassay that uses a set of histidine auxotrophic mutants of Salmonella typhimurium for detecting mutagenic and possibly carcinogenic compounds.
References in periodicals archive ?
The core principal of the Ames test is the use of amino acid-dependent strains of Salmonella typhimurium and Escherichia coli.
The objective of this study was to examine the features of the mushrooms by light microscope and to evaluate the toxicity of two selected wild mushrooms by Ames test in the presence and absence of metabolic activation by using TA98 and TA100 of Salmonella typhimurium bacterial strains.
The result of Ames Test on test sample (number of reverse mutated-colonies/Plate xsd n=6)
As the Ames tests were unequivocally negative (EMEA, 2008), on the basis of the HMPC nonclinical guideline no further genotoxicity testing of valerian root preparations is required (EMEA, 2006b).
a) The concentrated water extracts after the chlorination process were mutagenic to bacteria and genotoxic for mammal cells (human lymphocytes), evaluated through the Ames test and comet assay, respectively.
The S9 enzymatic activator is used in the Ames test to simulate the effect of organic compounds in the liver of mammals.
Thus, the SOS-Inductest detects agents that inhibit DNA replication (genotoxic agents), while the Ames test is effective to identify genetic damage that leads to gene mutations (mutagenic compounds).
Mini mutagenicity test: a miniaturized version of the Ames test used in a prescreening assay for point mutagenesis assessment.
Instead the FDA wants the Ames test plus either mouse lymphoma or chromosome aberration plus a further test, mouse micronucleus.
Assay for in vitro-in vivo mutagenicity of fecal and urinary samples by Ames test