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amide hydrolysis

   Also found in: Wikipedia 0.04 sec.
amide hydrolysis [′am‚īd hī′dräl·ə·səs]
(organic chemistry)
The cleavage of an amide into its constitutive acid and amine fragments by a net addition of water.


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(22) suggested that the formation of DEA from alachlor in rats and monkeys is dependent upon the conjugation of alachlor to glutathione, consequent enterohepatic circulation of this reduced glutathione (GSH) conjugate, conversion of the GSH conjugate to the secondary methylsulfide, and amide hydrolysis of the secondary methylsulfide to DEA (22).
 
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