amidine

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amidine

[′am·ə‚dēn]
(organic chemistry)
A compound which contains the radical CNHNH2.
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It is well known that the transfer of the amidino group of arginine to glycine to yield L-ornithine and guanidinoacetate (GM), which is catalyzed by L-arginine:glycine amidinotransferase, represents the first of two steps in the biosynthesis of Cr.
In contrast, treatment with 5 mg/kg cisplatin decreased the expression of L-arginine-glycine amidino transferase expression at day 1, and downregulation of guanidinoacetate methyltransferase was most prominent after 6 days.