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CTI BioPharma or the Company) (NASDAQ and MTA: CTIC) today announced that the United Kingdom's National Cancer Research Institute (NCRI) Haematological Oncology Clinical Studies Group has chosen to advance tosedostat, the Company's investigative oral aminopeptidase inhibitor, to the second stage of a randomized clinical trial of low-dose cytarabine plus or minus tosedostat in older patients with Acute Myeloid Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS).
This modification protects it against aminopeptidase degradation, and improves receptor activation and signal transduction in vitro (11).
Genetic characterization of pepP, which encodes an aminopeptidase P whose deficiency does not affect Lactococcus lactis growth in milk, unlike deficiency of the X-prolyl dipeptidyl aminopeptidase.
Plasmodium berghei: Induction of aminopeptidase in malaria-resistant strain of Anopheles gambiae.
Purification and characterization of a Cl- activated aminopeptidase from bovine skeletal muscle.
The results observed with tosedostat in acute myeloid leukemia add to a growing body of data showing the anti-tumor activity of this aminopeptidase inhibitor and the potential of using this approach to treat blood-related cancers," Alan K.
Release pattern of aminopeptidase from Biomphalaria glabrata hemocytes subjected to high-level bacterial challenge.
Aminopeptidases (APs) generally are zinc metalloenzymes used in clinical chemistry as markers of disease, and APs also play a physiological role in the regulation of several biologically active peptides (4).
CTI) (NASDAQ and MTA: CTIC) today announced the upcoming presentations of data highlighting pacritinib, an oral multikinase inhibitor with dual activity against JAK2 and FLT3, and tosedostat, an oral selective inhibitor of aminopeptidases, at the 56[sup.
1992), natural killer cell-like activity (Morsey & De Guise 2003), and apoptosis (Sunila & LaBanca 2003) as well as humoral factors including lysozymes, aminopeptidases, phospholipase C, antimicrobial peptides, and lectins (Mohandas & Cheng 1985, Kamiya et al.
2) In addition, two or more aminopeptidases may attack the same substrate.
Tosedostat is a first-in-class selective inhibitor of aminopeptidases, which are required by tumor cells to provide amino acids necessary for growth and tumor cell survival.