through the bloodstream and into the brain, binding to amyloid plaques
PKC Isozymes Regulate Amyloid Plaque
and Neurofibrillary Tangle Metabolism
Further observation of Japanese Creutzfeldt-Jacob disease with widespread amyloid plaques
During the course of our research, we also developed a greater understanding of how the vaccine works to clear amyloid plaques
out of the brain and prevent additional plaques from forming.
For decades now, scientists have known about two lesions that are characteristic of Alzheimer's disease - amyloid plaques
and neurofibrillary tangles - that are found in the brains of all affected individuals.
In preclinical studies, EVP-0962 has demonstrated a significant reduction in amyloid plaques
, which are believed to be a cause of Alzheimer's disease, and reversed behavioral deficits.
When amyloid accumulates and aggregates in the Alzheimer's disease process, amyloid deposits as either structures known as amyloid plaques
around neuronal cells or deposits of amyloid in the blood vessels of the brain.
They found that currently-available medications prescribed for conditions such as hypertension, depression, and insomnia were found to either to block or to enhance the accumulation of beta-amyloid, the component of amyloid plaques
The data from the phase III studies further confirm the potential application of 18F flutemetamol as an imaging agent to detect beta amyloid plaques
dissolve the amyloid plaques
that are present in the brains of patients with
Studies have implicated amyloid plaques
in the disease, but nobody has proved that they cause it.
At 13 months, virtually all of the mice immunized with AN-1972 had no detectable amyloid plaques
in their brains.