Bexarotene, currently used to treat non-Hodgkin lymphoma has been investigated by researchers at the University of Cambridge and has been shown to interfere with the development of amyloid protein
in worms, if given in the very early stages of the amyloid plaque formation.
Chemical typing of amyloid protein
contained in formalin-fixed paraffin-embedded biopsy specimens.
Characterization of spherical amyloid protein
from a prolactin-producing pituitary adenoma.
The amyloid protein
inflicts damage by interacting with an enzyme called Amyloid Beta Alcohol Dehydrogenase (ABAD) and releasing toxic substances which kill brain cells.
Biopsy the affected organ * Congo red binding and green birefringence under polarized light * Fibril structure on electron microscopy * X-ray crystallography and infrared spectroscopy to confirm the characteristic cross beta-pleated sheet * Biochemical and/or immunohistochemical identification of the major amyloid protein
* For patients with the AL type of amyloid: Immunohistochemical staining: demonstration of kappa and lambda chains in plasma cells Molecular genetic methods: differentiation between poly- and monoclonal B cells Step 2.
synuclein, Alzheimer s disease amyloid protein
APP, TDP-43 and FUS).
The latest tests, in the US, found vaccines can help patients with lower levels of the toxic amyloid protein
which builds up in Alzheimer's sufferers, destroying the vital links between brain cells, the Daily Express reported.
Washington, Nov 3 ( ANI ): A new study has revealed that high blood-sugar levels, such as those linked with Type 2 diabetes, make beta amyloid protein
associated with Alzheimer's disease dramatically more toxic to cells lining blood vessels in the brain.
Professor Jerry Turnbull, from the university's Institute of Integrative Biology, said: "We are targeting an enzyme, called BACE, which is responsible for creating the amyloid protein
Prevention efforts for Alzheimer's focus on a mutation that affects the gene PSEN1, which is involved in the production amyloid protein
These target the accumulation of beta amyloid protein
deposits in the brain which are a key feature of Alzheimer's.
Emphasizing the diversity of peptide systems, membrane assemblies, and biological phenomena investigated using in vitro and in vivo research studies in the past few years, this book surveys the latest progress in understanding the role of lipids and membranes in the formation of amyloid protein