androgen insensitivity syndrome

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androgen insensitivity syndrome

[¦an·drə·jən in‚sen·sə′tiv·ə·dē ‚sin‚drōm]
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The AR gene is located on the X chromosome, and a loss of function of the gene results in androgen-insensitivity syndrome.
Mutations affecting the same region of the DNA-binding domain have also been implicated in androgen-insensitivity syndromes and prostate cancer (13, 14).