ACE inhibitor

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Related to Angiotensin converting enzyme inhibitors: Angiotensin receptor blocker, Beta blockers, Losartan, Calcium channel blockers

ACE inhibitor

(ā'sē'ē`, ās) or

angiotensin-converting enzyme inhibitor

(ăn'jēōtĕn`sĭn), drug used to reduce elevated blood pressure (see hypertensionhypertension
or high blood pressure,
elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
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), to treat congestive heart failurecongestive heart failure,
inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.
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, and to alleviate strain on hearts damaged as a result of a heart attack (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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). ACE inhibitors block production of an enzyme that helps convert the protein angiotensin 1 into angiotensin 2, a protein that makes blood vessels constrict and promotes retention of fluid, raising blood pressure. Thus ACE inhibitors act to widen the blood vessels and make it easier for the heart to pump blood through the body. captopril (Capoten), ramipril (Altace), and enalapril (Vasotec) are commonly used ACE inhibitors. Angiotensin-receptor blockers (ARBs), such as losartan (Cozaar) and valsartan (Diovan), reduce hypertension by displacing angiotensin 2 from receptors on the surface of cells. ARBs are used as alternatives to the less expensive ACE inhibitors because they have fewer side effects.
References in periodicals archive ?
Hsu, Bates, Kuperman & Curhan (2001), in their study, "Blood pressure and angiotensin converting enzyme inhibitor use in hypertensive patients with chronic renal insufficiency," sought to investigate actual clinical management of hypertension in 3,089 ambulatory patients with CKD by using medical record information from a Massachusetts hospital.
Current standard of care for CKD is treatment with blood pressure lowering agents that affect the renin-angiotensin system, including Angiotensin Converting Enzyme inhibitors (ACEi) and Angiotensin Receptor Blockers (ARBs).
Objective: To compare efficacy of calcium channel blockers (CCBs) with angiotensin converting enzyme inhibitors (ACEIs) in the treatment of elderly men (age more than 55 years) with essential hypertension.
An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from India medicinal plants.
Bennett Neuropsychiatric Research Award and was also a winner of the American Heart Association Discovery Award for work on the development of angiotensin converting enzyme inhibitors.
Angioedema: Angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin converting enzyme inhibitors, including PRINIVIL.

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