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ACE inhibitor
(redirected from Angiotensin-converting enzyme inhibitors)

   Also found in: Dictionary/thesaurus, Medical, Legal, Wikipedia 0.01 sec.
ACE inhibitor (ā'sē'ē`, ās) or angiotensin-converting enzyme inhibitor (ăn'jēōtĕn`sĭn), drug used to reduce elevated blood pressure (see hypertension hypertension or high blood pressure, elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
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), to treat congestive heart failure congestive heart failure, inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.
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, and to alleviate strain on hearts damaged as a result of a heart attack (see infarction infarction, blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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). ACE inhibitors block production of an enzyme that helps convert the protein angiotensin 1 into angiotensin 2, a protein that makes blood vessels constrict and promotes retention of fluid, raising blood pressure. Thus ACE inhibitors act to widen the blood vessels and make it easier for the heart to pump blood through the body. captopril (Capoten), ramipril (Altace), and enalapril (Vasotec) are commonly used ACE inhibitors.

Angiotensin-receptor blockers (ARBs), such as losartan (Cozaar) and valsartan (Diovan), reduce hypertension by displacing angiotensin 2 from receptors on the surface of cells. ARBs are used as alternatives to the less expensive ACE inhibitors because they have fewer side effects.



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Evidence from subsequent analyses of ALLHAT and other clinical outcome trials confirm that neither alpha blockers, angiotensin-converting enzyme inhibitors, nor calcium channel blockers surpass thiazide-type diuretics (at appropriate dosage) as initial therapy for reduction of cardiovascular or renal risk," the authors wrote.
Drugs that prevent ischemic events, or lessen their impact, such as anticoagulants, statins, angiotensin-converting enzyme inhibitors, and aldosteron antagonists, all reduce the incidence of sudden death.
SEATTLE -- Angiotensin-converting enzyme inhibitors that cross the blood-brain barrier slow mental decline by about 50% relative to the decline seen in patients on other antihypertensives, an observational study of 1,074 hypertensive subjects followed for a median of 6 years shows.
 
 
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angiotensin precursor
Angiotensin Receptor 1 Blockers
Angiotensin receptor blocker
Angiotensin receptor blocker
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angiotensin sensitivity test
Angiotensin Type 1 Receptor Antagonists
Angiotensin Type 2
Angiotensin type-2
Angiotensin-1-Converting Enzyme
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Angiotensin-Converting Enzyme Dysfunction Syndrome
Angiotensin-Converting Enzyme Homolog
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Angiotensin-Converting Enzyme-Like Activity
Angiotensin-II Receptor Blocker
Angiotensin-receptor blocker
Angiotensin-receptor blocker
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Angiotensins
Angiotensins
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angiotonin
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angiotripsy
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Angiotropic Large Cell Lymphoma
 
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