sup], NRARP encodes a small evolutionarily conserved protein containing two ankyrin repeats which is a component of a negative feedback system to attenuate Notch pathway-mediated signaling.
Background: The Notch-regulated ankyrin repeat protein (NRARP) is recently found to promote proliferation of breast cancer cells.
The presence of 6 conserved ankyrin repeats
in SgI[kappa]B and its close phylogenetic relationship with other I[kappa]Bs strongly suggest that SgI[kappa]B belongs to the I[kappa]B superfamily.
inhibitor of NF- B binds NF-B through specific ankyrin repeats
of the C-terminus.
These are proteins with eukaryote-like domains, such as ankyrin repeats
and tetratricopeptide repeats (TPR), which are likely to mediate protein-protein interactions (Siegl et al.
The intracellular domain contains six ankyrin repeats
, the final motif found in Notch.
The center has discovered that B cell scaffold protein with ankyrin repeats
(BANK), a kind of adapter molecule, inhibits the immune response of the B cell.
This gene encodes a 153-160 kDa protein with at least 11 N-terminal ankyrin repeats
and a C-terminus with several tandem repeats but no homology with other proteins.