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(also vermifuge, helminthagogue), a preparation used to treat worm diseases, or helminthiases. The action of different anthelmintics varies. Some preparations, such as Heptylresorcine and Phenasal, damage the cuticle (integument) of helminths, while other preparations, such as santonin, ditrazin, piperazine, and naphtammone, alter the tone and mobility of parasites. Anthelmintics expel helminths from the patient’s body and are used when helminths infest the intestine and its communicating organs (liver, pancreas). Anthelmintics are also used to kill helminths.

Piperazine acts on the neuromuscular system of ascarids, which are subsequently excreted with feces. Phenasal destroys the integument of various tapeworms, including beef tapeworms, dwarf tapeworms, and broad tapeworms. They are then digested in the intestine and their residue is excreted. Chloxyl kills Siberian liver fluke in the liver and pancreas. The parasite is then eliminated into the intestine. Other anthelmintics, such as ditrazin and antimony preparations, destroy helminths, such as filiariae and schistosomes, in the blood, lymphatics, and tissues. Some antihelmintics, such as ditrazin and Chloxyl, are produced chemically. Others are obtained from plants, for example, from Artemisia cina or the extract of male fern.


Krotov, A. I. Osnovy eksperimental’noi terapii gel’mintozov. Moscow, 1973.


References in periodicals archive ?
Albendazole: a review of anthelmintic efficacy and safety in humans.
Implementation of this anthelmintic baiting strategy in suburban green spaces might significantly reduce risk for exposure by humans who use green spaces for recreation or live in close proximity to forested areas (9).
The anthelmintic effect of tolzan is more on the acid phosphatase activity than the alkaline phosphatase activity in Pallisentis nagpurensis.
Anthelmintics are essential for worm control and, to avoid anthelmintic resistance developing through frequent use and mis-use, a strategy must be developed.
The effectiveness of mebendazole as an anthelmintic was evaluated at three concentrations: 120 mg/L, 160 mg/L, and 200 mg/L.
Albendazole has become the anthelmintic of choice and offers good CSF penetration.
5) Treatment is difficult, combining careful surgical removal of cysts and anthelmintic therapy, (6) but is usually successful for infections occurring in Canada.
Although perhaps better known for its anthelmintic role, Artemisia absinthium (wormwood) has also been shown to suppress TNF-alpha and other interleukins in vitro.
The present study describes the proximate composition, antifungal and anthelmintic activity of solvent extracts of the macrolichen R.
61) It also has anthelmintic activity against the sheep worm parasite Trichostrongylus colubriformis.
It has been reported that Cucurbita maxima has antidiabetic, hepatoprotective, anthelmintic, antihypertensive, anticancer and antihypercholesterolemic features [29].
The tribals of Chitteri Hills, Dharmapuri District, Tamil Nadu, India use leaves of the plant as anthelmintic, antiasthmatic, anticholesterolemic, antiseptic, antispasmodic, diaphoretic, diuretic, stomachic, and antidiabetic (Kadhirvel et al, 2010).