Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs
In contrast, current clinical practice is generally to reserve ablation therapy for patients who have failed at least one antiarrhythmic drug
Several promising novel antiarrhythmic drugs
that are in early- to mid-stage development have the potential to offer profound safety advantages over current therapies.
Based on the severity of symptoms, HCM patients with non-permanent AF will be treated with either the rate control strategy ([beta]-blockers/calcium channel blocker) or the rhythm control strategy (PV ablation, antiarrhythmic drugs
, or radiofrequency ablation of the LA).
But the treatment of fetal arrhythmias is complex, since it involves giving a pregnant woman antiarrhythmic drugs
Since proton pump inhibitors (PPIs) have fewer side effects and are less expensive than antiarrhythmic drugs
or electrotherapy, therapy of GERD in patients with PAF might be an attractive alternative to the conventional and often not completely successful therapy of PAF.
Next, antiarrhythmic drugs
, including propafenone (1 mg/kg) intravenously, sotalol (100-200 mg/[m.
The final chapter of the handbook lists the side effects, dosing, and clinical trial results for class I, II, III, and IV antiarrhythmic drugs
For patients on antiarrhythmic drugs
, syncope occurred in 3.
This absence of any detectable effect on QTcF, confirming the atrial selectivity of XEN-D0103, is an important safety attribute for a new atrial fibrillation drug, since many current antiarrhythmic drugs
can lead to significant QT-interval prolongation and further arrhythmia problems.
9: Commonly Prescribed Antiarrhythmic Drugs
33 Table 3.
The study, called First Line Radiofrequency Ablation versus Antiarrhythmic Drugs
for Atrial Fibrillation Treatment: A Multicentre Randomized Trial (RAAFT), (LB02-1) was a multicenter, unblinded, parallel-arm clinical trial involving 127 patients with paroxysmal recurrent AFib.