Titer

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titer

[′tī·tər]
(chemistry)
The concentration in a solution of a dissolved substance as shown by titration.
The least amount or volume needed to give a desired result in titration.
The solidification point of hydrolyzed fatty acids.
(textiles)
The weight per unit length of yarn.
The number of filaments in reeled silk thread.

Titer

 

(in analytical chemistry), the concentration of a solution expressed as the amount (in grams) of a substance dissolved in 1 milliliter (ml) of solution or as the amount of any substance that reacts with 1 ml of the given solution. Accordingly, a distinction is made between the titer for a dissolved substance (for example, the titer of the solution of hydrochloric acid, THCI) and the titer for a substance to be determined (for example, the titer of the solution of hydrochloric acid for sodium hydroxide, THCI/NaOH). The titer is calculated from the formula T = P/V, where T is the titer of the solution in g/ml, P is the weight of the batch in g, and V is the volume of the measuring flask in ml. Solutions with a known titer, called standard solutions, are used in titrimetric analysis.


Titer

 

in immunochemical analysis, the maximum or optimum dilution of antigens, antibodies, or complement at which a positive reaction between antigens and antibodies can be recorded or the reaction of one or both components can be registered against a standard. In some cases, such as complement fixation, the maximum antigen concentration at which sensitized erythrocytes can still be lysed is taken as the antigen titer. Determination of the titer is useful in making a quick estimate of the activity of immune serums.

Three kinds of titration are used in immunochemical analysis. In one method, pipettes are used to add different amounts of the material being titrated to identical volumes of the solvent or for successive transfer of a mixture of the material and solvent to test tubes containing an identical quantity of solvent; in the latter case, equal volumes of the material, solvent, and mixture to be transferred are usually taken, which produces twofold dilutions. The second method is similar, except that capillary tubes are used and the volumes are measured from the number of drops. Glass loops capable of holding strictly standard volumes of liquid are used in automatic titration.

N. A. DORFMAN


Titer

 

(titre), in the textile industry, a number used to rate the thickness of fibers and yarns (chiefly silk). The titer is expressed as the product of the cross-sectional area of a fiber or yarn and the density of its material (or as the ratio of the weight of a fiber or yarn to the length). The titer came into use in the 18th century. A unit known as a legal titer has been used since 1900; it is numerically equivalent to the weight in grams of a yarn 9 km in length. In the USSR the tex replaced the titer in 1956.

References in periodicals archive ?
6% at the end of 6 months, and at the end of 9 months, only 8 (42%) patients had lost the protective antibody titer.
However, the homozygotes of the resistant allele A were found to present the lowest HI antibody titer to AIV after boosting vaccination, indicating the negative effects of the resistant allele A for the fitness of chicken to AIV, even if positive selection on this gene has been observed (Li et al.
Preimmunization and postimmunization pneumococcal antibody titers in children with recurrent infections.
The above phenomenon was very noticeable in the case of antibody titer and WBC counts.
Finally, although the difference in antibody titers in males and females reached statistical difference, this had no effect on specificity values for the various healthy age groups, which were identical to those in the population not divided by gender.
Pretravel titers of [greater than or equal to] 40 for [greater than or equal to] 1 influenza viruses were defined as protective antibody titers.
The co-primary immunogenicity endpoints for the seroconversion rate and the proportion of subjects with a minimum post-vaccination HI antibody titer of 1:40 are presented in Table 4.
05) vaccination responses but, contrary to expectations, there was a tendency to higher antibody titers with increasing levels of AF-alb.
Negative for antibodies (IgG and IgM) to West Nile virus by ELISA; sample not available for PRNT (d) nd indicates that the antibody titer was not determined.
In looking at the effect of multiple vaccinations, they found that although vaccinees generally showed a slight increase in antibody titer after a second vaccination, additional vaccinations--anywhere from 1 to 12 more--did not result in any further increase in long-term antibody production.
In accordance with our selection criteria, all 28 persons seroconverted (rise in antibody titer from <20 to [greater than or equal to] 40) to the pandemic (H1N1) 2009 virus; follow-up antibody titers ranged from 40 to 320 (Figure).
Furthermore, the antibody titer cutoff of 1:40 used in this study does not guarantee protection from infection, and the question remains as to whether the vaccine offers cross-protection against other H5N1 strains, he noted.

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