antibody-dependent cell-mediated cytotoxicity


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Related to antibody-dependent cell-mediated cytotoxicity: antibody-dependent cell-mediated cytotoxicity (ADCC)

antibody-dependent cell-mediated cytotoxicity

[‚ant·i‚bäd·ē di¦pen·dənt ‚sel¦mēd·ē‚ād·əd ‚sī·tō·täk′sis·əd·ē]
(immunology)
An immunologic response in which an immunologic effector cell binds to a target cell coated with antibodies, triggering a series of metabolic events that leads to lysis of the target cell.
References in periodicals archive ?
Results showed high correlation with results of antibody-dependent cell-mediated cytotoxicity (ADCC) experiments, without the variability due to biological complexity and statistical noise.
TG20 has enhanced antibody-dependent cell-mediated cytotoxicity (ADCC), a key feature useful in the treatment of cancer and auto-immune diseases, and it has been shown to have 10-fold enhanced ADCC when compared side by side with rituximab in assays performed with B-cell chronic lymphocytic leukemia, or B-CLL, patient cancer cell isolates.
It has been designed to have significantly improved antibody-dependent cell-mediated cytotoxicity (ADCC), therefore enhancing a central mechanism for tumour cell killing and potentially providing increased efficacy than traditional anti-cancer antibodies.

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