antibody-dependent cell-mediated cytotoxicity

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Related to Antibody-dependent cellular cytotoxicity: antibody-dependent cell-mediated cytotoxicity (ADCC)

antibody-dependent cell-mediated cytotoxicity

[‚ant·i‚bäd·ē di¦pen·dənt ‚sel¦mēd·ē‚ād·əd ‚sī·tō·täk′sis·əd·ē]
(immunology)
An immunologic response in which an immunologic effector cell binds to a target cell coated with antibodies, triggering a series of metabolic events that leads to lysis of the target cell.
References in periodicals archive ?
PENZBERG, Germany -- To date, more than 125 peer-reviewed studies using Roche's (SWX:RO)(SWX:ROG)(Pink Sheets:RHHBY) xCELLigence System have been published, spanning a diverse group of applications, including cell invasion and migration of cancer cells (1), receptor activity assays (2), compound induced cytotoxicity (3), antibody-dependent cellular cytotoxicity (4), virus-mediated cytopathogenicity (5) and others (6).
IgA-mediated immune effector responses such as phagocytosis, antibody-dependent cellular cytotoxicity, and cytokine synthesis and release are primarily mediated through FcAR.
In nonclinical studies, elotuzumab has been shown to induce antibody-dependent cellular cytotoxicity (ADCC) against primary myeloma cells and is currently in Phase I/II clinical development.

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