anticoagulant

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Related to Anticoagulant drug: warfarin

anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
dosage of another new anticoagulant drug, rivaroxaban, in acute coronary syn-drome (ACS) patients also treated with aspirin and clopidogrel.
Patients who take anticoagulant drugs like Coumadin[R] should be aware that some studies have shown that the omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) found in fish oil can prolong bleeding times.
In most cases, doctors treat unstable angina by giving patients anticoagulant drugs such as heparin.
The GORE PROPATEN Vascular Graft, which features the anticoagulant drug heparin anchored to the luminal surface, was cleared by the U.
Professor Peter Verhamme, Department of Vascular Diseases, University of Leuven, who presented the results at the ASH meeting, commented: "The results from the first Phase I study with TB-402 show that this novel human monoclonal antibody is safe and well-tolerated, an important first step in the development of this new anticoagulant drug.
Other notable updates to the guidelines include a suggestion to use a formal scoring system to assess patient risk and help guide the choice between the two management options; longer use of the antiplatelet drug clopidogrel (for up to 1 year in all patients); and a broadening of anticoagulant drug options to include two newer agents, fondaparinux and bivalirudin, in addition to the older drugs low-molecular-weight heparin and unfractionated heparin.
In tests with about 50 sheep, external blood filters containing the bacterial enzyme heparinase removed 99 percent of the anticoagulant drug heparin within about 15 minutes.
Late in 2006, for example, three infants died, and three others were harmed, by a massive overdose of the anticoagulant drug Heparin at a hospital in Indianapolis.
But the safety analysis of the results from this study, which showed that enoxaparin triggered more major bleeding complications than did unfractionated heparin (UFH), was complicated by the fact that a large number of patients received a dose of an anticoagulant drug that was different from their assigned study drug.
We are very excited about recent development progress at Regado, and we are convinced we have an extraordinary reversible anticoagulant drug profile emerging from the clinical data.
It is designed to address the gap in clinical performance between prosthetic and vein grafts by bonding the anticoagulant drug heparin to the surface of the graft using proprietary heparin end-point covalent bonding.
5 Anticoagulant Drug Market: Revenues by Class, 2011 Table 3.

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