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Many women hear about the teratogenic potential of antiepileptics and decide to stop epilepsy treatment entirely.
The use of antiepileptic drugs does not appear to raise the risk of suicide beyond the increased risk already associated with the underlying conditions for which patients take these medicines, according to results from a large database analysis.
In the alert, FDA recommended that "all patients treated with antiepileptic drugs should be monitored for suicidality and other unusual changes in behavior.
To our knowledge, there are no other published reports describing the RP-HPLC determination of antiepileptics in serum with direct injection.
The combination of findings strengthens a recommendation to avoid valproate as a first-line antiepileptic in women who may bear children, Dr.
Whereas clinical trials have shown clear evidence in favor of using antidepressants and antiepileptic medications alone in treating chronic pain, no studies have been designed to focus on the effect of combining antidepressants and antiepileptics for the treatment of neuropathic pain, wrote Dr.
Several studies have documented that the monitoring of antiepileptics is frequently done inappropriately.
Understand that morbidity, mortality, and increased risk of suicidal thoughts and behaviors are associated with epilepsy and other illnesses for which antiepileptic drugs are prescribed, independent of treatment with antiepileptic drugs.
In the larger study, 117 children, adolescents, and adults with EEG-confirmed PGTC seizures who were taking one or two concurrent antiepileptic drugs who also experienced three or more PGTC seizures during an 8-week baseline phase were randomized to adjunctive treatment with lamotrigine (58) or placebo (59).
The studies in the metaanalysis, published in April in a Canadian journal, compared rates of major malformations among women who reported taking valproic acid during the first trimester with rates among pregnant women who were taking other antiepileptic drugs (AEDs) and among women who were not taking any such drugs.
Youths with intermittent explosive disorder who remained compliant with their antiepileptic pharmacotherapy after discharge had significantly better outcomes than those who stopped the medication, Dr.