Chakraborty proposed that the chain of events that led a T cell to go forth and conquer involved a type of hysteresis; the response to signals from antigen-presenting cells
was based on recent encounters with other antigen-presenting cells
In addition to getting instructions from the antigen-presenting cells
, CD8 T cells need assistance from helper T cells to become effective killers.
If the antigen-presenting cells
produce the peanut protein robustly enough, the responsibility for the immune response might shift away from the IgE antibodies and mast cells.
A small peptide of the MBP nestles into a groove in the HLA-D molecule on an antigen-presenting cell
and the TCR, on an approaching immune T-cell, locks on to both.
When they analyzed "gene chips" to screen the disease-causing antigen-presenting cells
recovered from lungs with emphysema, they uncovered the gene for osteopontin, which promotes initiation of the inflammatory cascade that damages lungs.
Using conditions similar to those currently being evaluated in clinical trials, the researchers showed that electroporation increased numbers of antigen-presenting cells
at the site of administration that correlated with increases in antibody titers and T-cell responses to the encoded antigen.
He also found that Plasmodium GPI would hyperactivate macrophages and antigen-presenting cells
in the immune system, and cause red blood cells to adhere to blood vessels--all conditions associated with deadly cerebral malaria.
A patrolling T cell might then encounter one of these antigen-presenting cells
Abstract #1035: "Immunosuppressive properties of soluble extracellular domain of CD83 on antigen-presenting cells
of cynomologous monkey"
If the part of HIV that is similar to the antigen-presenting cells
were used as a vaccine, the antibodies generated against the vaccine material would also be capable of attacking the antigen-presenting cells
The Duke clinical trial uses an ex vivo (outside the body) process in which dendritic cells (the most efficient antigen-presenting cells
in the body) are isolated from the patient's blood, pulsed with telomerase RNA, and then used to vaccinate the patient.
The immune system is able to recognize tumor antigens through the activity of professional antigen-presenting cells