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(mī`grān), headache characterized by recurrent attacks of severe pain, usually on one side of the head. It may be preceded by flashes or spots before the eyes or a ringing in the ears, and accompanied by double vision, nausea, vomiting, or dizziness. The attacks vary in frequency from daily occurrences to one every few years.

Migraine affects women three times as often as men and is frequently inherited. Many disturbances, such as allergy, temporary swelling of the brain, and endocrine disturbances, have been suspected of causing some varieties of the disorder. Although the exact cause is unknown, evidence suggests a genetically transmitted functional disturbance of cranial circulation. The pain is believed to be associated with constriction followed by dilation of blood vessels leading to and within the brain.

Untreated attacks may last for many hours. Mild attacks are often relieved by common sedatives such as aspirin or codeine. Severe attacks may be treated with any of a variety of drugs, including a group called triptans, by injection or in the form of pills or nasal sprays. Certain beta-blockers, antiepileptic drugs, or tricyclic antidepressants may reduce the recurrence of migraines in some patients. Biofeedback is used in training people to recognize the warning symptoms and to practice control over the vascular dilation that initiates attacks.



(also hemicrania), a condition characterized by periodic headaches, usually localized in one half of the head. Women are most often affected by migraines, and in the majority of cases there is a hereditary tendency. The condition usually begins to manifest itself during puberty.

Migraines originate with changes in the tonus of intracranial and extracranial vessels. It is conjectured that first there is a spasm in the vessels and then a decrease in their tonus. As a result, the vessels dilatate abnormally. The headache attacks are accompanied by nausea, vomiting, and photophobia. Other symptoms include pallor or flushing, chilled hands and feet, weakness, shivering, and yawning. Patients usually complain of seeing bright flashes and zigzag lines; sometimes there is reduction or dimness of vision (ophthalmic migraine). Other symptoms are numbness of or tingling sensations in the extremities and, sometimes, the face and tongue. The symptomatic migraine is an indication of organic brain disease—for example, tumor, or vascular aneurysm.

Treatment entails normalization of vascular tonus, sedatives, and physical therapy.


Davidenkov, S. N., and A. M. Godinova. “K voprosu o nozologicheskikh granitsakh migrenei.” In Ocherki klinicheskoi nevrologii, fasc. 2. [Leningrad] 1964. [Collection of works.]



Recurrent paroxysmal vascular headache, commonly having unilateral onset and often associated with nausea and vomiting.


a throbbing headache usually affecting only one side of the head and commonly accompanied by nausea and visual disturbances
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Although it has not been demonstrated that these had antimigraine effect, they may be effective in combination with beta blockers prescribed by the attending doctor.
Coffee and tea provide 90% of dietary caffeine intake |2~, the remainder being derived from food additives, cocoa and proprietary analgesic and antimigraine medications.
Migraine (Acute) - An acute antimigraine agent that is not contraindicated in migraineurs with a history, symptoms, or signs of vascular disease for the treatment of migraine
1991), antimigraine, anti-hypercholesterolemia (Abe and Kaneda 1975) and antidiabetic activities (Yoshinari et al.
Further evidence of the underuse of aspirin for migraine comes from a 2013 review of national surveillance studies, (5) which found that in 2009, triptans accounted for nearly 80% of antimigraine analgesics prescribed during office visits.
LONDON -- The use of any form of acute antimigraine medication by patients with episodic migraine--be it single analgesics, combination analgesics, or triptans--exerted a protective effect against developing chronic migraine in a large, prospective, population-based study.
LONDON--Using any acute antimigraine medication--be it single or combination analgesics, or triptans--exerted a protective effect against developing chronic migraine in a large, prospective study of episodic migraineurs.
1]- Virtually the Interactions as Described receptor same as ACE-Is (see before antagonists ACE-Is above) Sympathomimetics Nasal Yes No decongestants ([alpha]- receptor) Ergot alkaloids Antimigraine Yes No drugs, bronchodilators ([[beta] .
The results are not as good as those achieved with standard antimigraine drugs, such as aspirin, antiemetics, trip-tans, or some of the new investigational drugs, but the availability of a noninvasive, nondrug treatment is important because it avoids the side effects of migraine medications, Dr.
1], agonist sumatriptan (an antimigraine medication) has been associated with fatigue, anxiety, and panic disorder.
Other than ergot drugs (contraindicated) and amitriptyline (concern for long-term neurotoxicity), antimigraine agents appear to be compatible with breast-feeding.