Antimutagens

Antimutagens

 

substances that decrease the frequency of mutations and inhibit the mutagenic effect of chemical or physical agents. Antimutagens may be arbitrarily divided into three groups. Those of the first group block the effect of automutagens, which arise naturally in the cells in the process of metabolism (antiautomutagens); an example of this is the enzyme catalase, which disrupts the mutagenic effect of hydrogen peroxide. These antimutagens assure the maintenance of a definite level of spontaneous mutations. The antimutagens of the second group diminish the effects of external, artificial physical (ionizing radiation, etc.) and chemical mutagens. Such antimutagens are sulfhydryl compounds, strong reducing agents of the type Na2S2O , certain alcohols, and carbonates. Antimutagens of these two groups may inhibit mutagens or compete with genetically important structures for interaction with a mutagen, or may act as reducing agents, and so forth. The third group includes enzyme systems that act directly on the level of hereditary structures, that is, to “correct” sections of the chromosome that have been damaged by a mutagen. The mutation effect may also be removed by physical effects of a given intensity (light, high or low temperatures, etc.).

IU. S. DEMIN

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Recently, natural plants have received much attention as sources of biologically active substances including antioxidants, antimicrobials, antimutagens and anticarcinogens nutraceuticals.
Fenwick In Dietary Anticarcinogens and Antimutagens Chemical and Biological Aspects The Royal Society of Chemistry Cambridge p.
Therefore, agents which can protect cellular membranes against IR and ROS/RNS will have potential benefits as radioprotectors, antioxidant and antimutagens (Odin 1997; Stavric 1994).
The use of antimutagens and anticarcinogens in everyday life is the most effective procedure for preventing human cancer and genetic ailment.
Even among antimutagen compounds, great care should be taken because a number of substances reported to be antimutagens or anticarcinogens have been shown to be mutagenic or carcinogenic themselves (Zeiger, 2003).
This increase is due largely to a search for and analysis of antimutagens, mainly from plant extracts.
Nakasugi T and K Komai Antimutagens in the Brazilian folk medicinal plant Carqueja (Baccharis trimera Less).
Citrus is used as a model for this approach in that citrus is a rich source of antioxidants, antimutagens, anticarcinogens, and chemoprotective compounds.
But current scientific thinking is that mutagens in our food are counterbalanced by other compounds that are antimutagens.
Major classes of CP agents include the antimutagens (oltipraz), antiproliferative agents (retinoids), antioxidants (vitamin E), and antiinflammatory agents (sulindac).